Novel Animal Models of HFpEF with Metabolic Comorbidities for Translational Drug Efficacy Studies

Time: 11:00 am
day: Day One

Details:

  • Discuss the limitations of high fat diet-induced obese mouse and rat models for HFpEF
  • Describe the Spontaneously Diabetic Torii (SDT) fatty rat and the LundMetS rat models to target HFpEF in the context of diabetic nephropathy and NASH
  • Present the free-choice diet-induced obese NASH hamster, a preclinical model with severe diastolic dysfunction and restrictive profile